The impact of the gut microbiome on toxigenic bacteria. (November 2021) - Koosha, Roohollah Zarei
Abstract: Millions of symbiotic and pathogenic microorganisms known as microbiota colonize the host body. The microbiome plays an important role in human health and colonizes hundreds of different species of multicellular organisms so that they are introduced as the metaorganisms. Changes in the microbial population of the gut microbiome may cause resistance to pathogenic bacteria-induced infection. Understanding the principles of Host-Microbiota Interactions (HMIs) is important because it clarifies our insight towards the mechanisms of infections established in the host. Interactions between the host and the microbiota help answer the question of how a microorganism can contribute to the health or disease of the host. Microbiota can increase host resistance to colonization of pathogenic species. Studying the HMIs network can in several ways delineate the pathogenic mechanisms of pathogens and thereby help to increase useful and novel therapeutic pathways. For example, the potentially unique microbial effects that target the distinct host or interfere with the endogenous host interactions can be identified. In addition, the way mutations in essential proteins in the host and/or in the microbes can influence the interactions between them may be determined. Furthermore, HMIs help in identifying host cell regulatory modules. Highlight: The human microbiota play a critical role as a double blade sword in health/disease establishment or formation. Gut Microbiota Colonize in the best microbial ratio to interact with f human immune system to form the best physiological hemostasis. Human Microbiome could consider as a host metabolite-producing regulator. Bacteria are able to sense chemicals and nutrients that are present in their surrounding and employ antimicrobial peptide against pathogens.