Defibrination syndrome with defective thrombin-fibrinogen reaction reversible by protamine. Issue 6 (November 1965)

• Record Type: Journal Article
• Authors: Bloom, A. L.; Campbell, Norah
• Is Part Of: Journal of clinical pathology. Volume 18:Issue 6(1965)
• Page Start: 786
• Page End: 789
• Publication Date: 1965-11
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.18.6.786
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : A patient with the obstetric defibrination syndrome successfully treated with human fibrinogen is described. The blood not only contained low levels of fibrinogen capable of clotting but also contained an inhibitor of the thrombin-fibrinogen reaction. This was neutralized in vitro with protamine but it was not heparin. Neither abnormality was detected by a latex agglutination test for plasma fibrinogen. The use of this test does not therefore exclude the diagnosis of the defibrination syndrome.