Batch reactor scale-up of the mixing-sensitive Bechamp reaction based on the heat pulse method. (16th January 2022)

• Record Type: Journal Article
• Authors: Camps, Lennart; Moens, Luc; Groth, Urs; Braeken, Leen; Kuhn, Simon; Thomassen, Leen C.J.
• Is Part Of: Chemical engineering science. Volume 247(2022)
• Publication Date: 2022-01-16
• Subjects: Heat pulse method -- Scale-up batch reactor -- Mixing scales -- Heat and mass mixing -- Mesomixing -- Mixing-sensitive solid–liquid reaction; Chemical engineering -- Periodicals; Génie chimique -- Périodiques; Chemical engineering; Periodicals; Electronic journals; 660
• DOI: 10.1016/j.ces.2021.116928
• Languages: English
• ISSNs: 0009-2509

Abstract

Graphical abstract: Highlights: Heat-mixing model from 1 to 35 L is developed for mesomixing-sensitive batch processes. A proof-of-concept scale-up of the mesomixing-sensitive Bechamp reaction validates the model. The model can be used to perform a scale-down from the pilot to lab scale. The model can support reactor design and optimisation. Abstract: Knowledge and control of mixing in batch processes can prevent yield losses during scale-up. Therefore, in this study, a new heat-mixing model based ono the measurement of the heat distribution after an applied heat pulse, is proposed. The model was developed to predict mesomixing and support scale-up, scale-down, and design and optimisation of batch reactors. The proposed model considers the influences of rotational speed, stirrer type, solvent, stirrer-to-tank diameter, liquid-height-to-tank diameter, injection time, and pumping number. A strong correlation between the mixing time of the heat pulse method and the mass-transfer coefficient of the mixing-sensitive Bechamp reaction was observed.