Nutrition acquisition by human immunity, transient overnutrition and the cytokine storm in severe cases of COVID-19. (October 2021)

• Record Type: Journal Article
• Authors: Yu, Boxuan; Yu, Ligen; Klionsky, Daniel J.
• Is Part Of: Medical hypotheses. Volume 155(2021)
• Publication Date: 2021-10
• Subjects: COVID-19 -- Cytokine storm -- Hyperinflammation -- Immune system -- Nutrition acquisition -- Overnutrition; Medicine -- Periodicals; Medicine -- Periodicals; Médecine -- Périodiques; Medicine; Periodicals; 610
• DOI: 10.1016/j.mehy.2021.110668
• Languages: English
• ISSNs: 0306-9877

Abstract

Abstract: The human immunity has a pivotal role in nutrition acquisition from the pathogens and damaged body tissue during the SARS-CoV-2 virus infection, which may lead to transient overnutrition in the patients, lead to lipotoxicity and further damage in non-adipose tissues, and cause hyperinflammation and cytokine storm in severe cases of COVID-19. In view of this, high-quality clinical trials on restrictive eating should be designed to investigate the possible benefits of food intake restriction on patients' recovery from COVID-19 disease.