The role of microbiota-gut-brain axis in neuropsychiatric and neurological disorders. (October 2021)

• Record Type: Journal Article
• Authors: Socała, Katarzyna; Doboszewska, Urszula; Szopa, Aleksandra; Serefko, Anna; Włodarczyk, Marcin; Zielińska, Anna; Poleszak, Ewa; Fichna, Jakub; Wlaź, Piotr
• Is Part Of: Pharmacological research. Volume 172(2021)
• Publication Date: 2021-10
• Subjects: ANS autonomic nervous system -- ASD autism spectrum disorder -- ASDs antiseizure drugs -- BBB blood-brain barrier -- BDNF brain derived neurotrophic factor -- B-GOS® Bimuno®-galactooligosaccharides -- CNS central nervous system -- CUMS chronic unpredictable mild stress -- DHA docosahexaenoic acid -- ECs endothelial cells -- ENS enteric nervous system -- EPA eicosapentaenoic acid -- FDR false discovery rate -- FMT fecal microbiota transplantation -- GF germ-free -- GI gastrointestinal -- HAMA Hamilton anxiety rating scale -- HAMD Hamilton rating scale for depression -- HPA hypothalamic-pituitary-adrenal -- IBS irritable bowel syndrome -- LPS lipopolysaccharide -- MS maternal separation -- NADH nicotinamide adenine dinucleotide -- NTG nitroglycerin -- PF pathogen-free -- PUFAs polyunsaturated fatty acids -- SCFAs short-chain fatty acids -- TJ tight junction -- TLR Toll-like receptor; Microbiota-gut-brain axis -- Neuropsychiatric disorders -- Neurological diseases -- Fecal microbiota transplantation -- Probiotics; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2021.105840
• Languages: English
• ISSNs: 1043-6618

Abstract

Abstract: Emerging evidence indicates that the gut microbiota play a crucial role in the bidirectional communication between the gut and the brain suggesting that the gut microbes may shape neural development, modulate neurotransmission and affect behavior, and thereby contribute to the pathogenesis and/or progression of many neurodevelopmental, neuropsychiatric, and neurological conditions. This review summarizes recent data on the role of microbiota-gut-brain axis in the pathophysiology of neuropsychiatric and neurological disorders including depression, anxiety, schizophrenia, autism spectrum disorders, Parkinson's disease, migraine, and epilepsy. Also, the involvement of microbiota in gut disorders co-existing with neuropsychiatric conditions is highlighted. We discuss data from both in vivo preclinical experiments and clinical reports including: (1) studies in germ-free animals, (2) studies exploring the gut microbiota composition in animal models of diseases or in humans, (3) studies evaluating the effects of probiotic, prebiotic or antibiotic treatment as well as (4) the effects of fecal microbiota transplantation. Graphical Abstract: ga1