Functional abdominal pain disorders and patient- and parent-reported outcomes in children with inflammatory bowel disease in remission. Issue 10 (October 2021)

• Record Type: Journal Article
• Authors: Tran, Léa Chantal; Bridoux-Henno, Laure; Gastineau, Swellen; Dabadie, Alain; Carré, Emilie; Hugot, Jean-Pierre; Martinez-Vinson, Christine; Mosca, Alexis; Coopman, Stéphanie; Lamireau, Thierry; Enaud, Raphaël; Clouzeau, Haude; Bertrand, Valérie; Pigneur, Bénédicte; Ruemmele, Frank; Degas, Vanessa; Breton, Anne; Mas, Emmanuel; Lacotte, Édouard; Chaillou-Legault, Emilie; Caron, Nicolas; Languepin, Jane; Willot, Stéphanie; Bouazza, Ahlem; Spyckerelle, Claire; Dimitrov, Georges; Thomassin, Nadège; Djeddi, Djamal; Vanrenterghem, Audrey; Grandjean, Camille; Viala, Jérôme; Dupont-Lucas, Claire;
• Is Part Of: Digestive and liver disease. Volume 53:Issue 10(2021)
• Page Start: 1268
• Page End: 1275
• Publication Date: 2021-10
• Subjects: Fatigue -- Quality-of-life -- Anxiety -- Paediatrics -- Abdominal pain -- Inflammatory bowel disease; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; 616.33005
• DOI: 10.1016/j.dld.2021.05.034
• Languages: English
• ISSNs: 1590-8658

Abstract

Abstract: Background: Chronic abdominal pain occurs frequently in pediatric patients with inflammatory bowel disease (IBD) in remission. Aims: To assess the prevalence and factors associated with Functional Abdominal Pain Disorders among IBD children in remission (IBD-FAPD). Methods: Patients with IBD for > 1 year, in clinical remission for ≥ 3 months were recruited from a National IBD network. IBD-FAPDs were assessed using the Rome III questionnaire criteria. Patient- or parent- reported outcomes were assessed. Results: Among 102 included patients, 57 (56%) were boys, mean age (DS) was 15.0 (± 2.0) years and 75 (74%) had Crohn's disease. Twenty-two patients (22%) had at least one Functional Gastrointestinal Disorder among which 17 had at least one IBD-FAPD. Past severity of disease or treatments received and level of remission were not significantly associated with IBD-FAPD. Patients with IBD-FAPD reported more fatigue (peds-FACIT-F: 35.9 ± 9.8 vs. 43.0 ± 6.9, p = 0.01) and a lower HR-QoL (IMPACT III: 76.5 ± 9.6 vs. 81.6 ± 9.2, p = 0.04) than patients without FAPD, and their parents had higher levels of State and Trait anxiety than the other parents. Conclusions: Prevalence of IBD-FAPD was 17%. IBD-FAPD was not associated with past severity of disease, but with fatigue and lower HR-QoL.