Functional Ultrasound Imaging: A New Imaging Modality for Neuroscience. (15th October 2021)

• Record Type: Journal Article
• Authors: Deffieux, Thomas; Demené, Charlie; Tanter, Mickael
• Is Part Of: Neuroscience. Volume 474(2021)
• Page Start: 110
• Page End: 121
• Publication Date: 2021-10-15
• Subjects: CBV cerebral blood volume -- CPCA class-wise principal component analysis -- fUS functional ultrasound imaging -- ICA independent component analysis -- LDA linear discriminant analysis -- PET positron emission tomography -- PPC posterior parietal cortex -- rtPA recombinant tissue plasminogen activator -- SPECT single photon emission computed tomography -- ULM Ultrasound Localization Microscopy; ultrasound imaging -- ultrafast imaging -- functional ultrasound imaging -- Doppler -- ultrasound localization microscopy -- functional brain connectivity -- neurovascular coupling -- neuroimaging -- stroke; Neurochemistry -- Periodicals; Neurophysiology -- Periodicals; Neurology -- Periodicals; Neurochimie -- Périodiques; Neurophysiologie -- Périodiques; Neurochemistry; Neurophysiology; Electronic journals; Periodicals; Electronic journals; 612.8
• DOI: 10.1016/j.neuroscience.2021.03.005
• Languages: English
• ISSNs: 0306-4522

Abstract

Highlights: As fMRI, functional ultrasound imaging (fUS) is based on neurovascular coupling. fUS has a high spatio temporal resolution and sensitivity. fUS portability allows imaging in awake animals. fUS is promising for human neonates or per-operative surgery imaging. Abstract: Ultrasound sensitivity to slow blood flow motion gained two orders of magnitude in the last decade thanks to the advent of ultrafast ultrasound imaging at thousands of frames per second. In neuroscience, this access to small cerebral vessels flow led to the introduction of ultrasound as a new and full-fledged neuroimaging modality. Much as functional MRI or functional optical imaging, functional Ultrasound (fUS) takes benefit of the neurovascular coupling. Its ease of use, portability, spatial and temporal resolution makes it an attractive tool for functional imaging of brain activity in preclinical imaging. A large and fast-growing number of studies in a wide variety of small to large animal models have demonstrated its potential for neuroscience research. Beyond preclinical imaging, first proof of concept applications in humans are promising and proved a clear clinical interest in particular in human neonates, per-operative surgery, or even for the development of non-invasive brain machine interfaces.