Biology of AMPA receptor interacting proteins - From biogenesis to synaptic plasticity. (1st October 2021)

• Record Type: Journal Article
• Authors: Matthews, Peter M.; Pinggera, Alexandra; Kampjut, Domen; Greger, Ingo H.
• Is Part Of: Neuropharmacology. Volume 197(2021)
• Publication Date: 2021-10-01
• Subjects: AMPA receptor -- PDZ domain -- Auxiliary subunit -- AMPAR trafficking -- AMPAR gating; Neuropsychopharmacology -- Periodicals; Autonomic Agents -- Periodicals; Neuropsychopharmacologie -- Périodiques; Neuropsychopharmacology; Periodicals; Electronic journals; 615.78
• DOI: 10.1016/j.neuropharm.2021.108709
• Languages: English
• ISSNs: 0028-3908

Abstract

Abstract: AMPA-type glutamate receptors mediate the majority of excitatory synaptic transmission in the central nervous system. Their signaling properties and abundance at synapses are both crucial determinants of synapse efficacy and plasticity, and are therefore under sophisticated control. Unique to this ionotropic glutamate receptor (iGluR) is the abundance of interacting proteins that contribute to its complex regulation. These include transient interactions with the receptor cytoplasmic tail as well as the N-terminal domain locating to the synaptic cleft, both of which are involved in AMPAR trafficking and receptor stabilization at the synapse. Moreover, an array of transmembrane proteins operate as auxiliary subunits that in addition to receptor trafficking and stabilization also substantially impact AMPAR gating and pharmacology. Here, we provide an overview of the catalogue of AMPAR interacting proteins, and how they contribute to the complex biology of this central glutamate receptor. This article is part of the special Issue on 'Glutamate Receptors – AMPA receptors'. Highlights: Comprehensive overview of AMPA receptor interacting proteins. Covers all currently known AMPA receptor interaction partners. Discusses auxiliary proteins and transiently interacting trafficking proteins.