Disseminated intravascular coagulation in paediatrics. Issue 2 (18th August 2016)

• Record Type: Journal Article
• Authors: Rajagopal, Revathi; Thachil, Jecko; Monagle, Paul
• Is Part Of: Archives of disease in childhood. Volume 102:Issue 2(2017)
• Page Start: 187
• Page End: 193
• Publication Date: 2016-08-18
• Subjects: Disseminated intravascular coagulation -- Paediatrics -- Diagnosis -- Management; Children -- Diseases -- Periodicals; Infants -- Diseases -- Periodicals; 618.920005
• DOI: 10.1136/archdischild-2016-311053
• Languages: English
• ISSNs: 0003-9888

Abstract

Abstract : Disseminated intravascular coagulation (DIC) in paediatrics is associated with significant morbidity and mortality. Although there have been several recent advances in the pathophysiology of DIC, most of these studies were done in adults. Since the haemostatic system is very different in early life and changes dramatically with age, creating a variety of challenges for the clinician, delay in the diagnosis of DIC can happen until overt DIC is evident. In this review article, we report the aetiology, pathophysiology, clinical manifestations, diagnostic tests and a management algorithm to guide paediatricians when treating patients with DIC.