1695 Mothers with Systemic Lupus Erythematosus and Neonatal Lupus. What you need to Know. A Presentation of 5 Cases. (October 2012)

• Record Type: Journal Article
• Authors: Castillo, M Trabazo del; Martínez-Baylach, J; Flinkenstein, B; Galdós, H; Herrera, C; Sais, G
• Is Part Of: Archives of disease in childhood. Volume 97(2012)Supplement 2
• Page Start: A479
• Page End: A479
• Publication Date: 2012-10
• Subjects: Children -- Diseases -- Periodicals; Infants -- Diseases -- Periodicals; 618.920005
• DOI: 10.1136/archdischild-2012-302724.1695
• Languages: English
• ISSNs: 0003-9888

Abstract

Abstract : Aim: Neonatal lupus (NL) is a rare disease (1/12000–1/20000 newborns). It appears in the neonatal period of newborns of mothers with systemic lupus erythematosus (SLE) or other connective tissue diseases. It's caused by the transfer of antibodies (Anti-Ro/Anti-La) from the mother to the fetus through the placenta. We recall the main features of the NL and the management of the child who have a mother with SLE. Methods: We present 5 cases of mother-child diagnosed with SLE or NL. Four cases corresponds to mothers diagnosed with SLE (two or them, with children diagnosed of NL), and the other case is a NL with an asymptomatic mother without the diagnosis of SLE until this moment. Results: Two or the four mothers diagnosed with SLE had children with NL (one with dermatologic clinic and the other with cardiac symptoms). These two mothers presented antibodies (Anti-Ro/Anti-La). The other two mothers didn't present these antibodies, so they had healthy children. The fifth case was a newborn with a healthy mother, who was diagnosed with NL with dermatological features. After this, the mother was studied and had Anti-Ro/Anti-La antibodies. No child diagnosed of NL had blood or liver disorders. Conclusions: We should study the children of mothers with SLE, particularly those with positive Anti-Ro/Anti-La antibodies, with the purpose of diagnosis of NL (particularly dermatological, cardiac, haematological and liver features). If we suspect NL in a child of an asymptomatic mother, the presence of Anti-Ro/Anti-La antibodies in the mother and the newborn should be studies to confirm the diagnosis.