Progression on metastatic neuroendocrine carcinoma from a recurrent prolactinoma: a case report. Issue 2 (1st February 2002)

• Record Type: Journal Article
• Authors: Sironi, M; Cenacchi, G; Cozzi, L; Tonnarelli, G; Iacobellis, M; Treré, D; Assi, A
• Is Part Of: Journal of clinical pathology. Volume 55:Issue 2(2002)
• Page Start: 148
• Page End: 151
• Publication Date: 2002-02-01
• Subjects: pituitary carcinoma -- prolactinoma -- metastasis, proliferating index -- electron microscopy; ACTH, adrenocorticotrophin -- CT, computed tomography -- GH, growth hormone -- MRI, magnetic resonance imaging -- PCNA, proliferating cell nuclear antigen -- PRL, prolactin; Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : A 54 year old man was referred to the department of neurosurgery for frontal headache and vomiting. The patient was known in the department because of previous multiple surgery for a locally invasive pituitary prolactinoma (eight years, three years, and one year previously). The neurological examination revealed a frontal mass, which adhered to the dura, suggesting a meningioma. One year later, a left temporal metastasis was removed. Three months later, the patient died, with spinal metastases, of massive lung embolism. Histology revealed a progression of adenohypophyseal prolactinoma on neuroendocrine carcinoma, with an increase in proliferating indexes and modification of hormone production. This study documents a 10 year history of a rare prolactin producing pituitary carcinoma, which metastasised via liquoral flow.