A therapeutic oxygen carrier isolated from Arenicola marina decreases amanitin-induced hepatotoxicity. (September 2021)

• Record Type: Journal Article
• Authors: Le Daré, Brendan; Ferron, Pierre-Jean; Bellamri, Nessrine; Ribault, Catherine; Delpy, Eric; Zal, Franck; Lagente, Vincent; Gicquel, Thomas
• Is Part Of: Toxicon. Volume 200(2021)
• Page Start: 87
• Page End: 91
• Publication Date: 2021-09
• Subjects: Amanitin -- Oxygen carrier -- M101 -- Hepatocyte -- Hepatotoxicity; Toxins -- Periodicals; Venom -- Periodicals; 615.9
• DOI: 10.1016/j.toxicon.2021.07.004
• Languages: English
• ISSNs: 0041-0101

Abstract

Abstract: The amanitins (namely α- and β-amanitin) contained in certain mushrooms are bicyclic octapeptides that, when ingested, are responsible for potentially lethal hepatotoxicity. M101 is an extracellular hemoglobin extracted from the marine worm Arenicola marina . It has intrinsic Cu/Zn-SOD-like activity and is currently used as an oxygen carrier in organ preservation solutions. Our present results suggest that M101 might be effective in reducing amanitin-induced hepatotoxicity and may have potential for therapeutic development. Graphical abstract: Image 1 Highlights: α- and β-amanitin lead to cell death and mitochondrial reactive oxygen species production in differentiated HepaRG cells. M101 is effective in reducing amanitin-induced cell death and mitochondrial reactive oxygen species production in vitro. M101 might be effective in reducing amanitin-induced hepatotoxicity and may have potential for therapeutic development.