Correction of overactive bladder with botulinum toxin type A (BTX-A). (September 2021)

• Record Type: Journal Article
• Authors: Grishin, Andrey; Spaska, Anastasiya; Kayumova, Lyailya
• Is Part Of: Toxicon. Volume 200(2021)
• Page Start: 96
• Page End: 101
• Publication Date: 2021-09
• Subjects: Overactive bladder -- Botulinum toxin type A -- Bladder dysfunction -- Patients' quality of life -- Urinary incontinence -- Urinary diary; Toxins -- Periodicals; Venom -- Periodicals; 615.9
• DOI: 10.1016/j.toxicon.2021.07.005
• Languages: English
• ISSNs: 0041-0101

Abstract

Abstract: One of the most common dysfunction is overactive bladder. The clinical symptoms are associated with an involuntary contraction of the detrusor muscle of the urethra. Drugs are the basis of overactive bladder therapy. However, the duration of drug therapy is limited due to the frequent development of side effects. The study aimed to examine the efficacy of using botulinum toxin type A (BTX-A) in patients with overactive bladder. A total of 90 patients with overactive bladder (mean age 39.86 ± 3.47 years; 59 (65.6%) women and 31 (34.4%) men) divided into two groups (45 patients each) were examined: Group 1 included patients without imperative urinary incontinence, and Group 2 included patients with imperative urinary incontinence. Patients in both groups underwent intravesical injection of 200 units of botulinum toxin type A (Xeomin). The BTX- A for treating patients with overactive bladder reduces clinical symptoms, increases the functional volume of the bladder, and facilitates an improvement in the life quality of patients. The use of BTX-A in patients suffering from overactive bladder and not responding to drug therapy with m-cholinolytics is effective and safe, which allows recommending this treatment method to correct the studied bladder dysfunction in such patients. Highlights: Bladder hyperactivity is a common disorder of urination. Botulinum toxin type A is effective in bladder hyperactivity. The use of botulinum toxin type A improves the quality of life in urinary disorders.