Antiheparin activity of some human blood protein fractions and their possible relationship to thrombosis. Issue 3 (May 1965)

• Record Type: Journal Article
• Authors: Dewhurst, F.; Poller, L.
• Is Part Of: Journal of clinical pathology. Volume 18:Issue 3(1965)
• Page Start: 339
• Page End: 344
• Publication Date: 1965-05
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.18.3.339
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : In view of the possible relationship to thrombosis the `anti-heparin' activity of blood protein fractions was studied. Serum and plasma were separated by continuous paper curtain electrophoresis and two different groups of fractions with anti-heparin activity found. One group was associated with the fast γ globulins and the other with the α globulins. The fast γ activity appeared to be identical with the contact activation product (activated factors XI and XII). The α globulin activity is different from any of the known serum clotting factors. This activity may be due to a previously unrecognized clotting factor or may be a coagulant property of certain blood proteins which act by binding heparin. The clinical implications of these findings are discussed. It is suggested that the fast γ globulin anti-heparin fraction may be identical with Wessler's serum thrombotic accelerator and the α globulin activity is a separate entity.