Exploring effects of EAAT polymorphisms on cognitive functions in schizophrenia. (May 2014)

• Record Type: Journal Article
• Authors: Spangaro, Marco; Bosia, Marta; Zanoletti, Andrea; Bechi, Margherita; Mariachiara, Buonocore; Pirovano, Adele; Lorenzi, Cristina; Bramanti, Placido; Smeraldi, Enrico; Cavallaro, Roberto
• Is Part Of: Pharmacogenomics. Volume 15:Number 7(2014)
• Page Start: 925
• Page End: 932
• Publication Date: 2014-05
• Subjects: cognitive impairment -- EAAT1 -- EAAT2 -- glutamate uptake -- schizophrenia; Pharmacogenomics -- Periodicals; 615.1
• DOI: 10.2217/pgs.14.42
• Languages: English
• ISSNs: 1462-2416

Abstract

Aim: To evaluate the effect of functional polymorphisms (rs4354668 and rs2731880) of the excitatory amino acid transporters (EAAT1 and 2) on the cognitive dysfunction that characterizes schizophrenia.Materials & methods: One hundred and ninety two subjects diagnosed with schizophrenia were assessed with Brief Assessment of Cognition in Schizophrenia, Wisconsin Card Sorting Test, Continuous Performance Test and N-back test and genotyped for rs4354668 and rs2731880.Results: ANOVA showed a significant difference among both EAAT1 and EAAT2 genotype groups on different cognitive measures. Worse performances were observed among carriers of the genotypes associated with lower EAAT expression.Conclusion: Results suggest that impaired activity and EAAT expression could influence cognitive performances in schizophrenia, thus representing a target of interest for development of pharmacological strategies aimed to improve cognition. Original submitted 14 October 2013; Revision submitted 24 February 2014