Familial risk for alcohol dependence and developmental changes in BMI: the moderating influence of addiction and obesity genes. (July 2014)

• Record Type: Journal Article
• Authors: Lichenstein, Sarah D; Jones, Bobby L; O'Brien, Jessica W; Zezza, Nicholas; Stiffler, Scott; Holmes, Brian; Hill, Shirley Y
• Is Part Of: Pharmacogenomics. Volume 15:Number 10(2014)
• Page Start: 1311
• Page End: 1321
• Publication Date: 2014-07
• Subjects: addiction -- BMI -- familial risk for alcoholism -- multiplex families -- obesity genes; Pharmacogenomics -- Periodicals; 615.1
• DOI: 10.2217/pgs.14.86
• Languages: English
• ISSNs: 1462-2416

Abstract

Abstract: Aim: Familial loading for alcohol dependence (AD) and variation in genes reported to be associated with AD or BMI were tested in a longitudinal study.Materials & methods: Growth curve analyses of BMI data collected at approximately yearly intervals and obesity status (BMI > 30) were examined.Results: High-risk males were found to have higher BMI than low-risk males, beginning at age 15 years (2.0 kg/m 2 difference; p = 0.046), persisting through age 19 years (3.3 kg/m 2 difference; p = 0.005). CHRM2 genotypic variance predicted longitudinal BMI and obesity status. Interactions with risk status and sex were also observed for DRD2 and FTO gene variation.Conclusion: Variation at loci implicated in addiction may be influential in determining susceptibility to increased BMI in childhood and adolescence. Orginal submitted 4 February 2014; Revision submitted 16 May 2014