Γδ T cells as a potential tool in colon cancer immunotherapy. (September 2014)

• Record Type: Journal Article
• Authors: Ramutton, Thiranut; Buccheri, Simona; Dieli, Francesco; Todaro, Matilde; Stassi, Giorgio; Meraviglia, Serena
• Is Part Of: Immunotherapy. Volume 6:Number 9(2014:Sep.)
• Page Start: 989
• Page End: 999
• Publication Date: 2014-09
• Subjects: colon cancer -- HDAC inhibitor -- immune surveillance -- immunotherapy -- MICA/B -- NKG2D-mediated killing -- Vγ9Vγ2 T cells; Immunotherapy -- Periodicals; 615.37
• DOI: 10.2217/imt.14.59
• Languages: English
• ISSNs: 1750-743X

Abstract

Γδ T cells are capable of recognizing tumor cells and exert potent cellular cytotoxicity against a large range of tumors, including colon cancer. However, tumors utilize numerous strategies to escape recognition or killing by patrolling γδ T cells, such a downregulation of NKG2D ligands, MICA/B and ULBPs. Therefore, the combined upregulation of T-cell receptorand NKG2D ligands on tumor cells and induction of NKG2D expression on γδ T cells may greatly enhance tumor killing and unlock the functions of γδ T cells. Here, we briefly review current data on the mechanisms of γδ T-cell recognition and killing of colon cancer cells and propose that γδ T cells may represent a promising target for the design of novel and highly innovative immunotherapy in patients with colon cancer.