Translating genetic risk factors for prostate cancer to the clinic: 2013 and beyond. (July 2014)

• Record Type: Journal Article
• Authors: Mikropoulos, Christos; Goh, Chee; Leongamornlert, Daniel; Kote-Jarai, Zsofia; Eeles, Rosalind
• Is Part Of: Future oncology. Volume 10:Number 9(2014)
• Page Start: 1679
• Page End: 1694
• Publication Date: 2014-07
• Subjects: biomarkers -- fine-mapping -- imputation -- single nucleotide polymorphisms -- targeted screening; Oncology -- Periodicals; 616.99405
• DOI: 10.2217/fon.14.72
• Languages: English
• ISSNs: 1479-6694

Abstract

ABSTRACT: : Prostate cancer (PrCa) is the most commonly diagnosed cancer in the male UK population, with over 40, 000 new cases per year. PrCa has a complex, polygenic predisposition, due to rare variants such as BRCA and common variants such as single nucleotide polymorphisms (SNPs). With the introduction of genome-wide association studies, 78 susceptibility loci (SNPs) associated with PrCa risk have been identified. Genetic profiling could risk-stratify a population, leading to the discovery of a higher proportion of clinically significant disease and a reduction in the morbidity related to age-based prostate-specific antigen screening. Based on the combined risk of the 78 SNPs identified so far, the top 1% of the risk distribution has a 4.7-times higher risk of developing PrCa compared with the average of the general population.