Anti-Müllerian hormone as an ovarian reserve marker in young cancer women who undergo ovarian tissue cryopreservation. (June 2014)

• Record Type: Journal Article
• Authors: Fabbri, Raffaella; Macciocca, Maria; Melotti, Cristina; Pasquinelli, Gianandrea; Vicenti, Rossella; Bacchi Reggiani, Maria Letizia; Terribile, Daniela; Venturoli, Stefano
• Is Part Of: Future oncology. Volume 10:Number 8(2014)
• Page Start: 1343
• Page End: 1351
• Publication Date: 2014-06
• Subjects: anti-Müllerian hormone -- menstrual cycle -- ovarian reserve -- ovarian tissue cryopreservation -- primordial follicles; Oncology -- Periodicals; 616.99405
• DOI: 10.2217/fon.14.76
• Languages: English
• ISSNs: 1479-6694

Abstract

ABSTRACT: : Aim : To evaluate if anti-Müllerian hormone (AMH) is a reliable marker of ovarian reserve in young women undergoing ovarian tissue cryopreservation.Patients & methods : Relationships of serum AMH levels with primordial follicle density, age and reproductive hormones were investigated using the Pearson or Spearman correlation coefficient in 86 women with cancer (12–38 years) undergoing ovarian tissue cryopreservation. AMH variations through the menstrual cycle were assessed by the Kruskal–Wallis test. p < 0.05 was accepted as significant.Results : AMH positively correlated with primordial follicle density (p = 0.03), showed great interindividual variability at all ages and negatively correlated with estradiol (p = 0.007) in the early follicular phase. AMH did not vary across the menstrual cycle (p = 0.415).Conclusion: AMH appears a valid ovarian reserve marker in young cancer women.