Circulating levels of GDF15, MMP7 and miR-200c as a poor prognostic signature in gastric cancer. (May 2014)

• Record Type: Journal Article
• Authors: Blanco-Calvo, Moisés; Tarrío, Nuria; Reboredo, Margarita; Haz-Conde, Mar; García, Jorge; Quindós, María; Figueroa, Angélica; Antón-Aparicio, Luis; Calvo, Lourdes; Valladares-Ayerbes, Manuel
• Is Part Of: Future oncology. Volume 10:Number 7(2014)
• Page Start: 1187
• Page End: 1202
• Publication Date: 2014-05
• Subjects: biomarkers -- diagnostic -- gastric cancer -- GDF15 -- metastasis -- miR-200c -- MMP7 -- prognostic; Oncology -- Periodicals; 616.99405
• DOI: 10.2217/fon.13.263
• Languages: English
• ISSNs: 1479-6694

Abstract

ABSTRACT: : Aim: To analyze GDF15 and MMP7 serum levels as diagnostic biomarkers in gastric cancer (GC) patients. The prognostic value of GDF15 and MMP7 serum levels in combination with miR-200c blood expression was also analyzed.Patients & methods: Fifty-two GC and 23 control samples were included.Results: GDF15 and MMP7 proved to be powerful tools for GC diagnosis. Increased levels of GDF15 and MMP7 were associated with shorter progression-free survival and overall survival in univariate analysis. In multivariate analysis, the combination of high levels of GDF15, MMP7 and miR-200c was an independent predictor for death (p = 0.033).Conclusion: GDF15 and MMP7 serum levels have diagnostic value for GC. The combination marker formed by GDF15, MMP7 and miR-200c is indicative of adverse evolution in GC patients.