HDGF: a novel jack-of-all-trades in cancer. (December 2014)

• Record Type: Journal Article
• Authors: Bao, Cihang; Wang, Jianbo; Ma, Wei; Wang, Xintong; Cheng, Yufeng
• Is Part Of: Future oncology. Volume 10:Number 16(2014)
• Page Start: 2675
• Page End: 2685
• Publication Date: 2014-12
• Subjects: angiogenesis -- apoptosis -- epithelial-to-mesencyhmal transition -- hepatoma-derived growth factor -- metastasis -- molecular mechanisms -- prognosis -- PWWP/HATH domain -- serum levels -- tumorigenesis; Oncology -- Periodicals; 616.99405
• DOI: 10.2217/fon.14.194
• Languages: English
• ISSNs: 1479-6694

Abstract

ABSTRACT : HDGF is an important regulator of a broad range of cancer cell activities and plays important roles in cancer cell transformation, apoptosis, angiogenesis and metastasis. Such a divergent influence of HDGF on cancer cell activities derives from its multiple inter- and sub-cellular localizations where it interacts with a range of different binding partners. Interestingly, high levels of HDGF could be detected in patients' serum of some cancers. This review is focused on the role of HDGF in tumorigenesis and metastasis, and provides insight for application in clinical cancer therapy as well as its clinical implications as a prognostic marker in cancer progression.