Lower mean corpuscular hemoglobin concentration is associated with unfavorable prognosis of resected lung cancer. (November 2014)

• Record Type: Journal Article
• Authors: Qu, Xiao; Zhang, Tiehong; Ma, Honghai; Sui, Ping; Du, Jiajun
• Is Part Of: Future oncology. Volume 10:Number 14(2014)
• Page Start: 2149
• Page End: 2159
• Publication Date: 2014-11
• Subjects: lung cancer -- MCHC -- MCV -- survival; Oncology -- Periodicals; 616.99405
• DOI: 10.2217/fon.14.121
• Languages: English
• ISSNs: 1479-6694

Abstract

ABSTRACT : Background: The association of preoperative red blood cell indexes in non-anemic patients undergoing lung resections for non-small-cell lung cancer with recurrence-free survival (RFS) and overall survival (OS) has never been investigated.Methods: We retrospectively examined the impact of preoperative red blood cell indexes on RFS and OS and the relationships between the indexes and clinicopathological factors in lung cancer.Results: A total of 649 patients were evaluated. The mean corpuscular hemoglobin concentration was showed as an independent prognostic factor in all patients for OS (hazard ratio [HR]: 0.697; 95% CI: 0.502–0.969; p = 0.032) and RFS (HR: 0.688; 95% CI: 0.519–0.914; p = 0.010). The mean corpuscular volume was an independent prognostic factor in all patients for OS (HR: 0.589; 95% CI: 0.380–0.912; p = 0.018), but not for RFS (HR: 0.684; 95% CI: 0.461–1.015; p = 0.059).Conclusion: In conclusion, the results of this study suggest that mean corpuscular hemoglobin concentration is an independent prognostic factor for OS and RFS in non-small-cell lung cancer.