Postoperative radiotherapy with volumetric modulated arc therapy of lacrimal gland carcinoma: two case reports and literature review. (November 2014)

• Record Type: Journal Article
• Authors: Orlandi, Ester; Takanen, Silvia; Giandini, Tommaso; Iannacone, Eva; Fontanella, Walter; Locati, Laura; Carrara, Mauro; Bossi, Paolo; Bergamini, Cristiana; Granata, Roberta; Tombolini, Vincenzo; Ibba, Tullio; Licitra, Lisa; Pignoli, Emanuele; Fallai, Carlo
• Is Part Of: Future oncology. Volume 10:Number 14(2014)
• Page Start: 2111
• Page End: 2120
• Publication Date: 2014-11
• Subjects: adenoid cystic carcinoma -- carcinoma ex pleomorphic adenoma -- dosimetric evaluation -- lacrimal gland tumor -- postoperative intensity-modulated radiation therapy -- treatment planning -- VMAT; Oncology -- Periodicals; 616.99405
• DOI: 10.2217/fon.14.148
• Languages: English
• ISSNs: 1479-6694

Abstract

ABSTRACT : Aims: To evaluate technical issues and clinical outcomes after postoperative volumetric-modulated arc therapy (VMAT) in two cases of malignant lacrimal gland cancer.Patients & methods: Patients were treated by postoperative VMAT and post-treatment clinical outcomes were followed-up to 18 months.Results: Dosimetric results were acceptable and acute toxicity was manageable in both patients. No evidence of disease was found at latest follow-up. One patient underwent corneal transplant for central corneal ulceration, experiencing reduction of visual acuity.Conclusion: Postoperative VMAT for treatment of lacrimal gland tumors offers improved outcome, with manageable side effects. In the context of photon beam radiotherapy, VMAT emerged as a valuable treatment option for these malignant tumors.