Quantification of myocardial blood flow using PET to improve the management of patients with stable ischemic coronary artery disease. (September 2014)

• Record Type: Journal Article
• Authors: Ohira, Hiroshi; Dowsley, Taylor; Dwivedi, Girish; deKemp, Robert A; Chow, Benjamin J; Ruddy, Terrence D; Davies, Ross A; DaSilva, Jean; Beanlands, Rob SB; Hessian, Renee
• Is Part Of: Future cardiology. Volume 10:Number 5(2014)
• Page Start: 611
• Page End: 631
• Publication Date: 2014-09
• Subjects: CAD -- CBF -- CFR -- CMR -- CT -- MBF -- PET -- SPECT; Cardiology -- Research -- Periodicals; 616.12005
• DOI: 10.2217/fca.14.44
• Languages: English
• ISSNs: 1479-6678

Abstract

ABSTRACT : Cardiac PET has been evolving over the past 30 years. Today, it is accepted as a valuable imaging modality for the noninvasive assessment of coronary artery disease. PET has demonstrated superior diagnostic accuracy for the detection of coronary artery disease compared with single-photon emission computed tomography, and also has a well-established prognostic value. The routine addition of absolute quantification of myocardial blood flow increases the diagnostic accuracy for three-vessel disease and provides incremental functional and prognostic information. Moreover, the characterization of the vasodilator capacity of the coronary circulation may guide proper decision-making and monitor the effects of lifestyle changes, exercise training, risk factor modification or medical therapy for improving regional and global myocardial blood flow. This type of image-guided approach to individualized patient therapy is now attainable with the routine use of cardiac PET flow reserve imaging.