A positive family history of cancer or lifestyle factors may not explain the high incidence of early-onset colorectal cancer in India. (October 2014)

• Record Type: Journal Article
• Authors: Raman, Ratheesh; Kotapalli, Viswakalyan; Vamsy, Mohana; Patnaik, Sujit C; Srinivasulu, Mukta; Bashyam, Murali D
• Is Part Of: Colorectal cancer. Volume 3:Number 5(2014)
• Page Start: 409
• Page End: 416
• Publication Date: 2014-10
• Subjects: alcohol consumption -- colorectal cancer -- diet -- early-onset colorectal cancer -- genetic background of cancer -- smoking; Colon (Anatomy) -- Cancer -- Periodicals; Rectum -- Cancer -- Periodicals; 616.994347
• DOI: 10.2217/crc.14.31
• Languages: English
• ISSNs: 1758-194X

Abstract

SUMMARY : Aim: Colorectal cancer (CRC) patients from developing countries such as India exhibit distinct clinico-pathological characteristics including an early age of onset and predominant tumor localization in the rectum. However, the reason(s) for increased occurrence among the young is not clear.Materials & methods: In the current study, we performed a comparative analysis of several epidemiological features in early and late-onset CRC patients from India including association with familial syndromes, diet and lifestyle habits.Results: Surprisingly, there was no significant association of any epidemiological variable with early-onset CRC.Conclusion: Perhaps low penetrance syndromes and/or other genetic causes may be responsible for an early age of onset among Indian CRC patients.