Biomarkers in pediatric heart disease. (August 2014)

• Record Type: Journal Article
• Authors: Nawaytou, Hythem; Bernstein, Harold S
• Is Part Of: Biomarkers in medicine. Volume 8:Number 7(2014)
• Page Start: 943
• Page End: 963
• Publication Date: 2014-08
• Subjects: biomarker -- cardiomyopathy -- cardiotoxicity -- congenital heart disease -- heart failure -- heart transplant -- Kawasaki disease -- natriuretic peptides -- postoperative -- pulmonary hypertension; Biochemical markers -- Periodicals; 610.28
• DOI: 10.2217/bmm.14.37
• Languages: English
• ISSNs: 1752-0363

Abstract

A biomarker is a characteristic that can be used as an indicator of a biological state. A biomarker can be a clinical observation, laboratory test or an imaging parameter. In this review, we discuss the use of biomarkers in differentiating cardiac from noncardiac disease; predicting the prognosis of patients with heart failure, pulmonary hypertension and dilated cardiomyopathy; diagnosing subclinical cardiac involvement in muscular dystrophy and postchemotherapy cancer patients; detecting acute rejection following heart transplantation; diagnosing Kawasaki disease; aiding the management of postoperative cardiac patients; and managing both common (tetralogy of Fallot) and complex (single-ventricle physiology) congenital heart diseases.