Association of FSH with metabolic syndrome in postmenopausal women: a comparison with CRP, adiponectin and leptin. (August 2014)

• Record Type: Journal Article
• Authors: Stefanska, Anna; Ponikowska, Irena; Cwiklinska-Jurkowska, Malgorzata; Sypniewska, Grazyna
• Is Part Of: Biomarkers in medicine. Volume 8:Number 7(2014)
• Page Start: 921
• Page End: 930
• Publication Date: 2014-08
• Subjects: adiponectin -- C-reactive protein -- follicle-stimulating hormone -- leptin -- menopause -- metabolic syndrome; Biochemical markers -- Periodicals; 610.28
• DOI: 10.2217/bmm.14.49
• Languages: English
• ISSNs: 1752-0363

Abstract

Aim: The aim of this study was to evaluate the usefulness of follicle-stimulating hormone (FSH) determination in the postmenopausal women with metabolic syndrome (MetS) in a comparative analysis with biomarkers such as C-reactive protein (CRP), adiponectin, leptin and leptin-to-adiponectin ratio (L/A).Material & methods: 135 postmenopausal women with MetS and 153 without MetS were subjected to examinations.Results: The increase in the probability of MetS, when the value of the marker concentration decreased or increased by 1 standard deviation, was two times higher for FSH-based models than for models including CRP and leptin, and was similar to models including adiponectin and L/A. The areas under the ROC curves were 0.78 for FSH, 0.68 for CRP, 0.72 for leptin, 0.76 for adiponectin and 0.80 for L/A.Conclusions: Our results suggest that the FSH concentration assesses the probability of MetS similarly to L/A or adiponectin and better than CRP or leptin in postmenopausal women.