Successful treatment of chronic type B aortic dissection complicated by disseminated intravascular coagulopathy with recombinant human soluble thrombomodulin after thoracic endovascular aortic repair. (February 2022)

• Record Type: Journal Article
• Authors: Iida, Yasunori; Asano, Ryota; Hachiya, Takashi
• Is Part Of: Vascular. Volume 30:Number 1(2022)
• Page Start: 38
• Page End: 41
• Publication Date: 2022-02
• Subjects: TEVAR -- disseminated intravascular coagulopathy -- recombinant human soluble thrombomodulin; 616.13
• DOI: 10.1177/1708538121990123
• Languages: English
• ISSNs: 1708-5381

Abstract

Objectives: We report a case of successful thoracic endovascular aortic repair (TEVAR) of chronic type B aortic dissection complicated by disseminated intravascular coagulopathy. Methods: The patient suffered from chronic type B aortic dissection coexisting with a large false lumen and an intimal tear. He underwent TEVAR with left common carotid-left subclavian artery bypass. Results: The following day, the patient exhibited a bleeding tendency and marked subcutaneous hemorrhage. He had a low fibrinogen level, a low platelet count, and high levels of fibrin dimer product and D-dimer. We diagnosed the condition as disseminated intravascular coagulopathy and administered recombinant human soluble thrombomodulin (rhTM). The patient recovered successfully from disseminated intravascular coagulopathy and was discharged on postoperative day 6. Conclusions: We successfully treated a patient with chronic type B aortic dissection with a large intimal tear complicated by postoperative disseminated intravascular coagulopathy using TEVAR followed by rhTM administration. rhTM may be considered in patients with large intimal tear and false lumen.