Patterns of relapse and outcome of elderly multiple myeloma patients treated as front-line therapy with novel agents combinations. Issue 2 (2015)

• Record Type: Journal Article
• Authors: Lopez, Aurelio; Mateos, Maria-Victoria; Oriol, Albert; Valero, Marta; Martínez, Joaquín; Lorenzo, Jose Ignacio; Perez, Montserrat; Martinez, Rafael; de Paz, Raquel; Granell, Miguel; De Arriba, Felipe; Blanchard, M. Jesús; Peñalver, Francisco Javier; Bello, Jose Luis; Martin, Maria Luisa; Bargay, Joan; Blade, Joan; Lahuerta, Juan Jose; San Miguel, Jesús F.; de la Rubia, Javier
• Is Part Of: Leukemia research reports. Volume 4:Issue 2(2015)
• Page Start: 64
• Page End: 69
• Publication Date: 2015
• Subjects: Relapsed myeloma -- Elderly patients -- Patterns of relapse; Leukemia -- Periodicals; Lymphomas -- Periodicals; Multiple myeloma -- Periodicals; Leukemia -- Periodicals; Lymphoma -- Periodicals; Multiple Myeloma -- Periodicals; Hematologic Neoplasms -- Periodicals; Leukemia; Lymphomas; Multiple myeloma; Electronic journals; Periodicals; 616.9941905
• DOI: 10.1016/j.lrr.2015.09.002
• Languages: English
• ISSNs: 2213-0489

Abstract

Abstract: We report the characteristics of relapse, treatment response, and outcomes of 145 elderly patients with multiple myeloma in first relapse after front-line treatment with VMP or VTP. Reappearance of CRAB symptoms (113 patients) and more aggressive forms of disease (32 patients) were the most common patterns of relapse. After second-line therapy, 75 (51.7%) patients achieved at partial response and 16 (11%) complete response (CR). Overall survival was longer among patients receiving VMP as front-line induction (21.4 vs. 14.4 months, P =0.037), in patients achieving CR (28.3 vs. 14.8 months; P =0.04), and in patients without aggressive relapse (28.6 vs. 7.6 months; P =0.0007).