Cover Feature: On‐Chip Neo‐Glycopeptide Synthesis for Multivalent Glycan Presentation (Chem. Eur. J. 44/2020). Issue 44 (10th July 2020)

• Record Type: Journal Article
• Authors: Mende, Marco; Tsouka, Alexandra; Heidepriem, Jasmin; Paris, Grigori; Mattes, Daniela S.; Eickelmann, Stephan; Bordoni, Vittorio; Wawrzinek, Robert; Fuchsberger, Felix F.; Seeberger, Peter H.; Rademacher, Christoph; Delbianco, Martina; Mallagaray, Alvaro; Loeffler, Felix F.
• Is Part Of: Chemistry. Volume 26:Issue 44(2020)
• Page Start: 9655
• Page End: 9655
• Publication Date: 2020-07-10
• Subjects: click chemistry -- combinatorial chemistry -- laser-induced forward transfer -- lectin -- microarrays; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.202003015
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : Laser‐based patterning technology allows for flexible and rapid on‐surface microarray synthesis of peptide scaffolds. In combination with click chemistry, a multitude of neo‐glycopeptides can be directly produced on functionalized glass slides in the microarray format. Density and spatial distribution of carbohydrates can be easily tuned to obtain well‐defined glycan structures for multivalent display. Lectins reveal strong spacing‐, density‐, and ligand‐dependent binding to these multivalent structures. More information can be found in the Full Paper by F. F. Loeffler et al. on page 9954 .