Advances in Magnetic Nanoparticle-Driven Delivery of Gene Therapies towards Prostate Cancer. (15th September 2021)

• Record Type: Journal Article
• Authors: Panday, Raju; Abdalla, Ahmed M. E.; Neupane, Manisha; Khadka, Sujan; Kricha, Aymane; Yang, Guang
• Other Names: Shi Donglu Academic Editor.
• Is Part Of: Journal of nanomaterials. Volume 2021(2021)
• Publication Date: 2021-09-15
• Subjects: Nanostructured materials -- Periodicals; Nanotechnology -- Periodicals; Nanomatériaux; Nanostructured materials; Nanotechnology; Nanostructures; Nanotechnology; Periodicals; Fulltext; Internet Resources; Periodicals; 620.115
• DOI: 10.1155/2021/6050795
• Languages: English
• ISSNs: 1687-4110

Abstract

Abstract : Conventional treatment possibilities for one of the most common diseases among men, i.e., prostate cancer has several side effects. Gene-based therapy such as siRNA, CRISPR/Cas9, pDNA, and miRNA have emerged as an alternative, combating posttherapy side effects and drug resistance. Magnetic nanoparticles have been appropriately modified and functionalized to efficiently deliver the gene therapy-based active compounds to prostate tumor cells. The main purpose of this review article is to highlight the strategies currently being utilized for the treatment of prostate cancer using magnetic nanoparticles for delivery of genetic material using both the passive and active (ligand-based) targeting. It further discusses the challenges in efficient delivery of therapeutics to tumor sites and their remedial approaches. Finally, it provides a glimpse of future advances for tumor-specific modifications of magnetic nanoparticles to combat prostate cancer.