A Supramolecular Radical Dimer: High‐Efficiency NIR‐II Photothermal Conversion and Therapy. (13th September 2019)

• Record Type: Journal Article
• Authors: Tang, Bohan; Li, Wan‐Lu; Chang, Yincheng; Yuan, Bin; Wu, Yukun; Zhang, Ming‐Tian; Xu, Jiang‐Fei; Li, Jun; Zhang, Xi
• Is Part Of: Angewandte Chemie. Volume 131:Number 43(2019)
• Page Start: 15672
• Page End: 15677
• Publication Date: 2019-09-13
• Subjects: Organische Radikale -- Photothermische Konversion -- Selbstorganisation -- Supramolekulare Chemie -- Wirt-Gast-Systeme; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201910257
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Photothermal therapy at the NIR‐II biowindow (1000–1350 nm) is drawing increasing interest because of its large penetration depth and maximum permissible exposure. Now, the supramolecular radical dimer, fabricated by N, N′‐dimethylated dipyridinium thiazolo[5, 4‐d]thiazole radical cation (MPT .+ ) and cucurbit[8]uril (CB[8]), achieves strong absorption at NIR‐II biowindow. The supramolecular radical dimer (2MPT .+ ‐CB[8]) showed highly efficient photothermal conversion and improved stability, thus contributing to the strong inhibition on HegG2 cancer cell under 1064 nm irradiation even penetrating through chicken breast tissue. This work provides a novel approach to construct NIR‐II chromophore by tailor‐made assembly of organic radicals. It is anticipated that this study provides a new strategy to achieve NIR‐II photothermal therapy and holds promises in luminescence materials, optoelectronic materials, and also biosensing. Abstract : Hitzewelle : Wirtverstärkter intermolekularer Ladungstransfer ermöglichte die Herstellung eines supramolekularen Radikaldimers mit starker Absorption im biologisch relevanten NIR‐II‐Fenster und hoher Stabilität. Das Dimer zeigte eine hoch effiziente photothermische Konversion und starke Inhibition von Krebszellen durch photothermische Therapie mit NIR‐II‐Licht.