Development of Zinc‐Specific iCEST MRI as an Imaging Biomarker for Prostate Cancer. (17th September 2019)

• Record Type: Journal Article
• Authors: Yuan, Yue; Wei, Zhiliang; Chu, Chengyan; Zhang, Jia; Song, Xiaolei; Walczak, Piotr; Bulte, Jeff W. M.
• Is Part Of: Angewandte Chemie. Volume 131:Number 43(2019)
• Page Start: 15658
• Page End: 15663
• Publication Date: 2019-09-17
• Subjects: Kontrastmittel -- MRT -- Prostatakrebs -- Zink; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201909429
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: The healthy prostate contains the highest concentration of mobile zinc in the body. As this level decreases dramatically during the initial development of prostate cancer, in vivo detection of prostate zinc content may be applied for diagnosis of prostate cancer. Using 19 F ion chemical exchange saturation transfer magnetic resonance imaging (iCEST MRI) and TF‐BAPTA as a fluorinated Zn‐binding probe with micromolar sensitivity, we show that iCEST MRI is able to differentiate between normal and malignant prostate cells with a 10‐fold difference in contrast following glucose‐stimulated zinc secretion in vitro. The iCEST signal decreased in normal prostate cells upon downregulation of the ZIP1 zinc transporter. In vivo, using an orthotopic prostate cancer mouse model and a transgenic adenocarcinoma of the mouse prostate (TRAMP) model, a gradual decrease of >300 % in iCEST contrast following the transition of normal prostate epithelial cells to cancer cells was detected. Abstract : Zink‐Messung : Normales Prostatagewebe hat den höchsten Zinkanteil im Körper. Mit TF‐BAPTA als Zink‐spezifischer iCEST‐MRT‐Sensor für den Abbau von Zink wurde ein neuartiger Bildgebungsbiomarker entwickelt, der Anwendungen in der frühen Erkennung von Prostatakrebs finden kann.