Front Cover: One Way Traffic: Base‐to‐Backbone Hole Transfer in Nucleoside Phosphorodithioate (Chem. Eur. J. 43/2020). Issue 43 (22nd June 2020)

• Record Type: Journal Article
• Authors: Kaczmarek, Renata; Ward, Samuel; Debnath, Dipra; Jacobs, Taisiya; Stark, Alexander D.; Korczyński, Dariusz; Kumar, Anil; Sevilla, Michael D.; Denisov, Sergey A.; Shcherbakov, Viacheslav; Pernot, Pascal; Mostafavi, Mehran; Dembinski, Roman; Adhikary, Amitava
• Is Part Of: Chemistry. Volume 26:Issue 43(2020)
• Page Start: 9403
• Page End: 9403
• Publication Date: 2020-06-22
• Subjects: DNA damage -- hole transfer -- radicals -- radical ions -- radiation chemistry; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.202002714
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : The direction of hole transfer (unpaired spin) in the DNA‐component, occurring between base and modified phosphate, is depicted in the cover artwork. This process critically determines the DNA‐backbone damage. In one‐electron oxidized phosphorodithioate nucleotide, the hole is initially localized on guanine base as a cation radical (Gua .+ ). Next, via base‐to‐backbone hole transfer, the hole appears on phosphorodithioate as dithiyl radical. Cover art designed by Ariela Kaspi‐Kaneti, with contribution from Aditya Paul. More information can be found in the Full Paper by R. Dembinski, A. Adhikary, et al. on page 9495 .