Gold‐Speckled SPION@SiO2 Nanoparticles Decorated with Thiocarbohydrates for ASGPR1 Targeting: Towards HCC Dual Mode Imaging Potential Applications. Issue 48 (30th July 2020)

• Record Type: Journal Article
• Authors: Siciliano, Giulia; Corricelli, Michela; Iacobazzi, Rosa Maria; Canepa, Fabio; Comegna, Daniela; Fanizza, Elisabetta; Del Gatto, Annarita; Saviano, Michele; Laquintana, Valentino; Comparelli, Roberto; Mascolo, Giuseppe; Murgolo, Sapia; Striccoli, Marinella; Agostiano, Angela; Denora, Nunzio; Zaccaro, Laura; Curri, M. Lucia; Depalo, Nicoletta
• Is Part Of: Chemistry. Volume 26:Issue 48(2020)
• Page Start: 11048
• Page End: 11059
• Publication Date: 2020-07-30
• Subjects: ASGPR1 receptor -- bioconjugates -- gold/silica nanoparticles -- SPIONs -- thiocarbohydrate ligands; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.202002142
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: Efforts are made to perform an early and accurate detection of hepatocellular carcinoma (HCC) by simultaneous exploiting multiple clinically non‐invasive imaging modalities. Original nanostructures derived from the combination of different inorganic domains can be used as efficient contrast agents in multimodal imaging. Superparamagnetic iron oxide nanoparticles (SPIONs) and Au nanoparticles (NPs) possess well‐established contrasting features in magnetic resonance imaging (MRI) and X‐ray computed tomography (CT), respectively. HCC can be targeted by using specific carbohydrates able to recognize asialoglycoprotein receptor 1 (ASGPR1) overexpressed in hepatocytes. Here, two different thiocarbohydrate ligands were purposely designed and alternatively conjugated to the surface of Au‐speckled silica‐coated SPIONs NPs, to achieve two original nanostructures that could be potentially used for dual mode targeted imaging of HCC. The results indicated that the two thiocarbohydrate decorated nanostructures possess convenient plasmonic/superparamagnetic properties, well‐controlled size and morphology and good selectivity for targeting ASGPR1 receptor. Abstract : S‐glyco decorated metal/silica coated superparamagnetic nanostructures have been investigated as potential contrast agents for targeted dual‐mode imaging (MRI and X‐ray CT) of hepatocellular carcinoma.