Water-soluble silver(i) complexes with N-donor benzimidazole ligands containing an imidazolium core: stability and preliminary biological studies. Issue 33 (6th August 2021)

• Record Type: Journal Article
• Authors: Karataş, Mert Olgun; Özdemir, Namık; Sarıman, Melda; Günal, Selami; Ulukaya, Engin; Özdemir, İsmail
• Is Part Of: Dalton transactions. Volume 50:Issue 33(2021)
• Page Start: 11596
• Page End: 11603
• Publication Date: 2021-08-06
• Subjects: Chemistry, Inorganic -- Periodicals; Chemistry, Physical and theoretical -- Periodicals; Chemistry, Inorganic -- Periodicals; 546.05
• DOI: 10.1039/d1dt02008k
• Languages: English
• ISSNs: 1477-9226

Abstract

Abstract : We report the synthesis, characterisation and biological investigation of two novel water-soluble silver(i ) complexes with N-donor benzimidazoles containing an imidazolium core at the 2-position. Abstract : Herein, we report the synthesis, characterisation and preliminary biological evaluation of two novel silver(i ) complexes of type [AgL2 ](NO3 )3 (3 and 4 ) with ionic N-donor benzimidazoles. The complexes have been synthesized by the reaction of 1.5 equivalents of silver nitrate and N-donor benzimidazoles containing an imidazolium core at the 2-position (1 and 2 ) in ethanol. The X-ray analysis of 4 shows that it has two free imidazolium cores and the charge is balanced with three nitrate anions. A study by the combination of NMR, IR, LC-MS and elemental analysis techniques also suggests that the complexes have this structure both in the solid-state and solution. The complexes are highly soluble and stable in water. Cytotoxicity evaluation against four cancerous human cells and one non-cancerous human cell revealed that the complexes have no significant anti-growth effect. However, the complexes showed a remarkable antimicrobial effect at normalized minimum inhibitory concentrations (normalized MICs) in the range of 33–268 μM against a panel of microorganisms consisting of Gram-negative and Gram-positive bacteria, and fungi.