Donor cell origin of multiple myeloma occurring after allogeneic haematopoietic stem cell transplantation in a patient with refractory anaemia with ring sideroblast. Issue 3 (22nd December 2010)

• Record Type: Journal Article
• Authors: Kim, Young-Il; Kim, Hye-Ran; Shin, Myung-Geun; Lee, Young-Jin; Shin, Jong-Hee; Suh, Soon-Pal; Ryang, Dong-Wook
• Is Part Of: Journal of clinical pathology. Volume 64:Issue 3(2011)
• Page Start: 265
• Page End: 268
• Publication Date: 2010-12-22
• Subjects: Post-transplant lymphoproliferative disorder -- multiple myeloma -- donor origin -- haematology -- myeloma -- transplantation; Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.2010.084731
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Post-transplant lymphoproliferative disorder (PTLD) is a rare but life-threatening complication after solid organ and haematopoietic stem cell transplantation. A 40-year-old woman who was diagnosed as having refractory anaemia with ring sideroblast 6 years ago took an ABO mismatched, unrelated allogeneic haematopoietic stem cell transplantation (HSCT) from a 32-year-old healthy male donor. The bone marrow (BM) study was carried out because of progressing pancytopenia, serum biclonal gammopathy and a distorted ratio of serum level of free κ and λ light chain 138 days after HSCT. The BM examination showed an increased number of plasma cells (12% of total marrow cells) comprising mainly CD45−CD19−CD138+ malignant plasma cells with an immunoglobulin heavy-chain gene rearrangement. Conventional cytogenetics and molecular personal identification studies revealed that all BM cells were totally replaced by donor cells, thus indicating the donor cell origin of PTLD-multiple myeloma. The BM microenvironment of the recipient might be associated with the development of PTLD-multiple myeloma.