Nephrotic Syndrome with Heart Disease: A Reappraisal. Issue 5618 (7th September 1968)

• Record Type: Journal Article
• Authors: Hilton, P. J.; Jones, N. F.; Tighe, J. R.
• Is Part Of: BMJ. Volume 3:Issue 5618(1968)
• Page Start: 574
• Page End: 586
• Publication Date: 1968-09-07
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.3.5618.574-a
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : The evidence that heart failure alone may cause a nephrotic syndrome is inconclusive. Mercurial diuretics, which have also been implicated as a cause of the nephrotic syndrome, had been given in 23 of the 24 well-documented cases. Two cases of heart disease and nephrotic syndrome are described. Glomerular lesions were minimal on light microscopy, but thickening of the glomerular tuft basement membrane and partial fusion of the epithelial cell foot processes were apparent on elecronmicroscopy. The response to prednisone was such as to justify a trial of corticosteroid therapy in such cases despite the presence of cardiac disease.