Radiographic findings following irrigation of chronic perineal drain with hydrogen peroxide. (2015)

• Record Type: Journal Article
• Authors: Melin, Alyson A.; Heckman, Andrew M.; Hussain, Shahid; Thompson, Jon S.
• Is Part Of: International journal of surgery case reports. Volume 6(2015)
• Page Start: 263
• Page End: 265
• Publication Date: 2015
• Subjects: Hydrogen peroxide -- Chronic pelvic abscess -- Benign pneumoperitoneum; Surgery -- Periodicals; Surgical Procedures, Operative -- Periodicals; Surgery; Electronic journals; Periodicals; 617.005
• DOI: 10.1016/j.ijscr.2014.10.052
• Languages: English
• ISSNs: 2210-2612

Abstract

Highlights: Hydrogen peroxide exerts direct cytotoxicity by corrosion and lipid peroxidation. Hydrogen peroxide exerts indirect cytotoxicity by oxygen gas formation. With ingestion side effects from nausea to portal venous gas and death are reported. We describe a patient with a transperineal drain in a chronic pelvic cavity. Irrigation with hydrogen peroxide (H2 O2 ) led to significant pneumoperitoneum on CT. Benign pneumoperitoneum is noted with irrigation of a transperineal drain with H2 O2 . Abstract: INTRODUCTION: Hydrogen peroxide is a widely available agent used for irrigation and disinfecting. With misuse, significant side effects have been noted ranging from nausea to abdominal cramping to portal venous gas, air embolism and death. PRESENTATION OF CASE: We present an 81 year old male who developed a rectovesicular fistula following radiation for metastatic prostate cancer. He had recurrent bleeding and infections and underwent a pelvic exenteration which was complicated by a persistent pelvic abscess requiring placement of a transperineal drainage catheter. After months of persistent drainage, he noted decreased output and irrigated the catheter with 3% hydrogen peroxide. He presented to the emergency room with fever, diarrhea and abdominal cramping but no rebound or guarding. CT depicted free air in the pre-sacral space extending into the retroperitoneum and diffusely throughout the peritoneum. Given his clinical exam and upon review of imaging, we assumed his radiographic findings were related to the direct instillation of hydrogen peroxide into his chronic pelvic cavity. DISCUSSION: Hydrogen peroxide has been used therapeutically for over 100 years. Hydrogen peroxide exerts direct cytotoxicity by corrosion and lipid peroxidation and indirectly by oxygen gas formation. When the oxygen produced exceeds the solubility in the blood, arterial and venous gas embolism occur. It is this sequelae of hydrogen peroxide that is described most frequently in the literature. CONCLUSION: Instillation of hydrogen peroxide into a chronic pelvic cavity resulted in a benign pneumoperitoneum. This effect of hydrogen peroxide is a significant and potentially treatment altering radiographic finding.