3D 31P MRSI of the human brain at 9.4 Tesla: Optimization and quantitative analysis of metabolic images. Issue 5 (4th July 2021)

• Record Type: Journal Article
• Authors: Ruhm, Loreen; Dorst, Johanna; Avdievitch, Nikolai; Wright, Andrew Martin; Henning, Anke
• Is Part Of: Magnetic resonance in medicine. Volume 86:Issue 5(2021)
• Page Start: 2368
• Page End: 2383
• Publication Date: 2021-07-04
• Subjects: 9.4 T -- chemical shift imaging -- MRSI -- Phosphorus -- quantitative metabolic images -- ultrahigh field; Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.28891
• Languages: English
• ISSNs: 0740-3194

Abstract

Abstract : Purpose: To present 31 P whole brain MRSI with a high spatial resolution to probe quantitative tissue analysis of 31 P MRSI at an ultrahigh field strength of 9.4 Tesla. Methods: The study protocol included a 31 P MRSI measurement with an effective resolution of 2.47 mL. For SNR optimization, the nuclear Overhauser enhancement at 9.4 Tesla was investigated. A sensitivity correction was achieved by applying a low rank approximation of the γ‐adenosine triphosphate signal. Group analysis and regression on individual volunteers were performed to investigate quantitative concentration differences between different tissue types. Results: Differences in gray and white matter tissue 31 P concentrations could be investigated for 12 different 31 P resonances. In addition, the first highly resolved quantitative MRSI images measured at B0 = 9.4 Tesla of 31 P detectable metabolites with high SNR could be presented. Conclusion: With an ultrahigh field strength B0 = 9.4 Tesla, 31 P MRSI moves further toward quantitative metabolic imaging, and subtle differences in concentrations between different tissue types can be detected.