Clinical characteristics of immunoglobulin IgG4-related sclerosing cholangitis: Comparison of cases with and without autoimmune pancreatitis in a large cohort. Issue 10 (October 2021)

• Record Type: Journal Article
• Authors: Naitoh, Itaru; Kamisawa, Terumi; Tanaka, Atsushi; Nakazawa, Takahiro; Kubota, Kensuke; Takikawa, Hajime; Unno, Michiaki; Masamune, Atsushi; Kawa, Shigeyuki; Nakamura, Seiji; Okazaki, Kazuichi; Furumatsu, Keisuke; Sawai, Shigeaki; Goto, Takuma; Okumura, Toshikatsu; Suzuki, Daisuke; Otsuka, Masayuki; Kobori, Ikuhiro; Tamano, Masaya; Koizumi, Mitsuhito; Hiasa, Yoichi; Kawabe, Naoto; Hirooka, Yoshiki; Yamamoto, Satoshi; Asano, Yukio; Inui, Kazuo; Horiguchi, Akihiko; Watanabe, Hiroyuki; Toya, Daishu; Hatayama, Katsuko; Ueki, Toshiharu; Kinoshita, Norikatsu; Sugimoto, Mitsuru; Ohira, Hiromasa; Mukai, Tsuyoshi; Tomita, Eiichi; Iwata, Keisuke; Shimizu, Shogo; Suetsugu, Jun; Shimizu, Masahito; Tsuji, Keiji; Ishida, Ryoko; Ito, Masanori; Furukawa, Ryutaro; Sakamoto, Naoya; Araki, Masahiro; Tanno, Satoshi; Sakamoto, Yasunari; Ito, Tetsuhide; Takai, Satoshi; Ikeya, Shinichi; Yamada, Takanori; Kudara, Norihiko; Shimizu, Akinori; Hanada, Keiji; Ichiki, Yasunori; Kitada, Hideki; Hifumi, Michio; Kimura, Hiroyuki; Kurosaki, Masayuki; Izumi, Namiki; Sumi, Hajime; Haruta, Jun-ichi; Hayashi, Katsumi; Harada, Ryo; Inoue, Masafumi; Nakamura, Shinichiro; Ito, Tetsuya; Tomishima, Ko; Isayama, Hiroyuki; Oura, Kyoko; Masaki, Tsutomu; Shimokawahara, Naoto; Tanoue, Shirou; Maemura, Kousei; Ido, Akio; Mizushima, Ichiro; Kawano, Mitsuhiro; Yoshida, Katsunori; Naganuma, Makoto; Murata, Miki; Nishio, Akiyoshi; Fujita, Yuji; Teratani, Takuma; Matsubara, Shohei; Tamai, Hironao; Yoshida, Yuu; Azemoto, Ryousaku; Kamata, Ken; Watanabe, Tomohiro; Kurosu, Takahiro; Koizumi, Wasaburou; Fujita, Jun; Seki, Hideyuki; Ueda, Yasuhiro; Fukumoto, Takumi; Kousaki, Takuhiro; Uchida, Kazushige; Ochiai, Toshimasa; Kawasaki, Takeshi; Tanaka, Motohiko; Ishida, Etsuji; Notohara, Kenji; Mori, Hideaki; Mori, Toshiyuki; Kawabata, Hideaki; Miyata, Masatoshi; Sakagami, Junichi; Itoh, Yoshito; Shiokawa, Masahiro; Seno, Hiroshi; Watanabe, Noriko; Naitoh, Itaru; Kataoka, Hiromi; Aoki, Toshinori; Fujishiro, Mitsuhiro; Niihara, Toru; Nishimata, Hiroto; Mitoro, Akira; Yoshiji, Hitoshi; Yoshida, Motoyuki; Ikeda, Masafumi; Tomita, Kengo; Hokari, Ryota; Hayasaka, Kenji; Amano, Yuji; Shioji, Kazuhiko; Hayashi, Kazunao; Terai, Shuji; Nakajima, Michiko; Yamahana, Junya; Matsumoto, Ryusuke; Kikuchi, Hideaki; Kanamori, Akira; Kiriyama, Seiki; Iwatsu, Shinichi; Kato, Yuji; Horiguchi, Shigeru; Yagi, Takahito; Okada, Hiroyuki; Ohkawa, Kazuyoshi; Hirao, Motohiro; Hiramatsu, Naoki; Oza, Noriko; Imamura, Haruo; Baba, Takeshi; Nakano, Shigeru; Shinobi, Tetsuya; Ryozawa, Shomei; Motoya, Masayo; Nakase, Hiroshi; Kinoshita, Noboru; Ito, Kei; Miyake, Tatsuya; Kohge, Naruaki; Tobita, Hiroshi; Joshita, Satoru; Umemura, Takeji; Kawaguchi, Shinya; Ohno, Kazuya; Sonobe, Koichi; Satoh, Akihiko; Shimosegawa, Tooru; Miura, Fumihiko; Yagi, Minami; Sano, Keiji; Tanaka, Atsushi; Kin, Toshifumi; Katanuma, Akio; Koike, Kazuhiko; Miura, Shin; Masamune, Atsushi; Kawashima, Youhei; Kagawa, Tatehiro; Azuma, Seishin; Watanabe, Mamoru; Honjyo, Mitsuyoshi; Itoi, Takao; Honda, Akira; Kobayashi, Katsumasa; Asano, Toru; Kamisawa, Terumi; Mizuno, Suguru; Koike, Kazuhiko; Nishino, Takayoshi; Taniguchi, Hideaki; Tajiri, Kazuto; Yasuda, Ichiro; Tanaka, Yoshiya; Oe, Shinji; Harada, Masaru; Kurata, Masanao; Fukasawa, Mituharu; Enomoto, Nobuyuki; Kawaji, Yuki; Kitano, Masayuki; Nishise, Yuko; Hirakawa, Hidetoshi; Ishizawa, Tetsuya; Ueno, Yoshiyuki; Kaino, Miyuki; Fujimoto, Yuko; Sakaida, Isao; Kubota, Kensuke;
• Is Part Of: Digestive and liver disease. Volume 53:Issue 10(2021)
• Page Start: 1308
• Page End: 1314
• Publication Date: 2021-10
• Subjects: Autoimmune pancreatitis -- Cholangiocarcinoma -- IgG4-related disease -- IgG4-related sclerosing cholangitis -- Isolated IgG4-related sclerosing cholangitis -- Primary sclerosing cholangitis; Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; 616.33005
• DOI: 10.1016/j.dld.2021.02.009
• Languages: English
• ISSNs: 1590-8658

Abstract

Abstract: Background: The clinical characteristics of IgG4-related sclerosing cholangitis (IgG4-SC) especially without autoimmune pancreatitis (AIP) have not been investigated in a large cohort. Aims: To clarify the clinical characteristics of IgG4-SC and IgG4-SC without AIP. Methods: We retrospectively reviewed imaging, serology, other organ involvement (OOI) and histology of 872 patients with IgG4-SC who participated in a Japanese nationwide survey in 2019, and compared these items between IgG4-SC with and without AIP. Results: AIP was present in 83.7% (730/872) of IgG4-SC. In IgG4-SC, bile duct wall thickening was observed on ultrasound (528/650; 81.2%), computed tomography (375/525; 71.4%) and magnetic resonance imaging or cholangiopancreatography (290/440; 65.9%). An elevated serum IgG4 level (≥ 135 mg/dL) was found in 88.0% (322/366). IgG4-related OOI other than AIP was observed in 25.2% (211/836). The proportion of females was significantly higher in IgG4-SC without AIP (28.9% vs. 20.1%; p = 0.025). Hilar stricture was the most common cholangiographic type in IgG4-SC without AIP (39/107; 36.4%).There were no significant differences between IgG4-SC with and without AIP in the rates of bile duct wall thickening, elevated serum IgG4 level, or IgG4-related OOI. Conclusions: The clinical characteristics of IgG4-SC was similar between IgG4-SC with and without AIP in a large cohort.