Smart Asymmetric Hydrogel with Integrated Multi‐Functions of NIR‐Triggered Tunable Adhesion, Self‐Deformation, and Bacterial Eradication. Issue 19 (29th May 2021)

• Record Type: Journal Article
• Authors: Feng, Lan; Shi, Wenbin; Chen, Qin; Cheng, Huitong; Bao, Jianxu; Jiang, Chunji; Zhao, Weifeng; Zhao, Changsheng
• Is Part Of: Advanced healthcare materials. Volume 10:Issue 19(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-05-29
• Subjects: multifunctional hydrogels -- photothermal antibacterial properties -- self‐deformation -- tunable adhesion; Biomedical materials -- Periodicals; 610.28
• DOI: 10.1002/adhm.202100784
• Languages: English
• ISSNs: 2192-2640

Abstract

Abstract: Multifunctional hydrogels acting as wound dressing have received extensive attention in soft tissue repair; however, it is still a challenge to develop a non‐antibiotic‐dependent antibacterial hydrogel that has tunable adhesion and deformation to achieve on‐demand removal. Herein, an asymmetric adhesive hydrogel with near‐infrared (NIR)‐triggered tunable adhesion, self‐deformation, and bacterial eradication is designed. The hydrogel is prepared by the crosslinking polymerization of N ‐isopropylacrylamide and acrylic acid, during the sedimentation of conductive PPy‐PDA nanoparticles based on the polymerization of pyrrole (Py) and dopamine (DA). Due to the conversion capacity from NIR light into heat for PPy‐PDA NPs, the formed temperature‐sensitive hydrogel exhibits tissue adhesive as well as NIR‐triggered tunable adhesion and self‐deformation property, which can achieve an on‐demand dressing refreshing. Systematically in vitro / in vivo antibacterial experiments indicate that the hydrogel shows excellent disinfection capability to both Gram‐negative and Gram‐positive bacteria. The in vivo experiments in a full‐layer cutaneous wound model demonstrate that the hydrogel has a good treatment effect to promote wound healing. Overall, the asymmetric hydrogel with tunable adhesion, self‐deformation, conductive, and photothermal antibacterial activity may be a promising candidate to fulfill the functions of adhesion on skin tissue, easy removing on‐demand, and accelerating the wound healing process. Abstract : An asymmetric adhesive hydrogel integrated with multiple functionalities of near‐infrared‐triggered tunable adhesion, self‐deformation, and bacterial eradication is designed. Despite the non‐antibiotic‐dependent photothermal antibacterial activity, the hydrogel can also be a promising candidate to fulfill the functions of adhesion on skin tissue, easy removing on‐demand, and accelerating the wound healing process.