Cover Feature: Towards an Understanding of the Molecular Mechanisms of Variable Unnatural Base‐Pair Behavior: A Biophysical Analysis of dNaM‐dTPT3 (Chem. Eur. J. 56/2021). Issue 56 (21st September 2021)

• Record Type: Journal Article
• Authors: Karadeema, Rebekah J.; Morris, Sydney E.; Lairson, Luke L.; Krishnamurthy, Ramanarayanan
• Is Part Of: Chemistry. Volume 27:Issue 56(2021)
• Page Start: 13896
• Page End: 13896
• Publication Date: 2021-09-21
• Subjects: biopolymers -- nucleic acids -- nucleobases -- synthetic biology -- thermodynamics; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.202103397
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : A biophysical analysis of nucleic acid duplexes containing the unnatural hydrophobic base pair (d)NaM‐dTPT3 provides an understanding of the type of molecular level interactions that could contribute to variabilities in replication, transcription and translation in a semisynthetic organism. Such approaches could provide a basis for comprehending the behavior of other unnatural base pairs (spheres top left) with a view towards unrestricted expansion of the genetic alphabet and code (spheres bottom‐right) in a semisynthetic organism. More information can be found in the Full Paper by R. Krishnamurthy et al. (DOI: 10.1002/chem.202102348 ). Picture by Saurav Nagpal with the help of R.K. (background DNA image from www.canva.com).