Strategy for the multi‐component characterization and quality evaluation of volatile organic components in Kaixin San by correlating the analysis by headspace gas chromatography/ion mobility spectrometry and headspace gas chromatography/mass spectrometry. (15th September 2021)

• Record Type: Journal Article
• Authors: Yin, Jiaxin; Lin, Ruimei; Wu, Mengfan; Ding, Hui; Han, Lifeng; Yang, Wenzhi; Song, Xinbo; Li, Wenlong; Qu, Haibin; Yu, Heshui; Li, Zheng
• Is Part Of: Rapid communications in mass spectrometry. Volume 35:Number 21(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-09-15
• Subjects: Mass spectrometry -- Periodicals; 543.65
• DOI: 10.1002/rcm.9174
• Languages: English
• ISSNs: 0951-4198

Abstract

Abstract : Rationale: Kaixin San (KXS) is a prescription traditional Chinese medicine (TCM) with the effects of "tonifying the kidney and brain" and "improving memory". The volatile organic compounds (VOCs) in KXS could effectively improve senile dementia and depression, but only few studies have focused on the overall characterization of VOCs in KXS and the quantitative study of the main active components. Methods: We have developed a strategy to correlate the results from headspace gas chromatography/ion mobility spectrometry (HS‐GC/IMS) and headspace gas chromatography/mass spectrometry (HS‐GC/MS) for the comprehensive characterization of VOCs in KXS and the quantitative analysis of the main pharmacodynamic substances. Results: A totsal of 68 low molecular weight VOCs were identified in KXS by HS‐GC/IMS at room temperature and atmospheric pressure; 117 VOCs were identified and 10 components (isocalamenediol, α ‐asarone, β ‐asarone, methyl eugenol, isoeugenol methyl ether, camphor, anethol, 2, 4‐di‐tert‐butylphol, linalool, asarylaldehyde) as the quality markers of KXS based on HS‐GC/MS. Conclusions: This results from this study provide a foundation for quality control, pharmacodynamic mechanism research and further development of KXS, and provides more convincing data supporting the VOCs of other natural products.