Green Synthesis of Ag NP‐Decorated Poly(dopamine) Microcapsules for Antibacterial Applications. Issue 37 (5th October 2021)

• Record Type: Journal Article
• Authors: Hu, Qiyan; Zhou, Zhiyuan; Gao, Liwen; Zhou, Naijun; Chen, Yuanyan; Wang, Shaozhen
• Is Part Of: ChemistrySelect. Volume 6:Issue 37(2021)
• Page Start: 10054
• Page End: 10058
• Publication Date: 2021-10-05
• Subjects: Antimicrobial activity -- Cytotoxicity -- Green synthesis -- Nanoparticles -- Organic-inorganic hybrid composites; Chemistry -- Periodicals; 540.5
• DOI: 10.1002/slct.202102654
• Languages: English
• ISSNs: 2365-6549

Abstract

Abstract: The ability to synthesize Ag nanoparticle‐based composites under gentle conditions shows the promise to produce versatile antimicrobial agents. Herein, we report a green method for the synthesis of Ag NP‐decorated poly(dopamine) (Ag NP‐PDA) microcapsules. The synthesis involves the use of ZIF‐8 crystals as self‐sacrificed templates to produce PDA microcapsules followed by in situ reduction of Ag + to Ag 0 to form Ag NPs with catechol groups of the PDA microcapsules. The formation mechanism is supported by the results from transmission electron microscopy, powder X‐ray diffraction, Fourier‐transform infrared spectroscopy, and X‐ray photoelectron spectroscopy. We show that the as‐prepared Ag NP‐PDA microcapsule composites exhibit low cytotoxicity towards L929 cells but effective antimicrobial activity towards both E. coli and S. aureus. These results suggest the possibility of our method to prepare combined nanocomposite antimicrobial agents by loading additional antibiotics on the surface or into the microcapsule of the PDA support. Abstract : A green method is reported for the synthesis of Ag NP‐decorated poly(dopamine) (PDA) microcapsules. It combines templated synthesis of PDA microcapsules and in situ Ag NP decoration. The Ag NP‐PDA microcapsules show high biocompatibility but remarkable antimicrobial activity towards both E. coli and S. aureus at a low concentration of 2.5 mg mL −1, and the potential as support to load additional antibiotics to further improve their performance.