Further Study into Obstructive Jaundice and Ischaemic Renal Damage. Issue 5651 (26th April 1969)

• Record Type: Journal Article
• Authors: Baum, M.; Stirling, G. A.; Dawson, J. L.
• Is Part Of: BMJ. Volume 2:Issue 5651(1969)
• Page Start: 229
• Page End: 231
• Publication Date: 1969-04-26
• Subjects: Medicine -- Periodicals; Medicine -- Periodicals; Medicine; Periodicals; 610
• DOI: 10.1136/bmj.2.5651.229
• Languages: English
• ISSNs: 0007-1447

Abstract

Abstract : Renal ischaemia for one hour in two groups of Gunn rats, one with and the other without bile-duct ligation, produced comparable reversible renal tubular lesions in both groups. Since Gunn rats have an unconjugated hyperbilirubinaemia, which is unaffected by bile-duct ligation, it seems likely that the high levels of bilirubin glucuronide are responsible for sensitizing the renal tubules to ischaemia, possibly by depressing cell respiration.