Primary cilia and lipid raft dynamics. Issue 8 (25th August 2021)

• Record Type: Journal Article
• Authors: Nishimura, Yuhei; Yamakawa, Daishi; Uchida, Katsunori; Shiromizu, Takashi; Watanabe, Masatoshi; Inagaki, Masaki
• Is Part Of: Open biology. Volume 11:Issue 8(2021)
• Publication Date: 2021-08-25
• Subjects: primary cilia -- lipid raft dynamics -- Akt -- adipogenesis -- cancer; Biology -- Periodicals; 570
• DOI: 10.1098/rsob.210130
• Languages: English
• ISSNs: 2046-2441

Abstract

Abstract : Abstract : Primary cilia, antenna-like structures of the plasma membrane, detect various extracellular cues and transduce signals into the cell to regulate a wide range of functions. Lipid rafts, plasma membrane microdomains enriched in cholesterol, sphingolipids and specific proteins, are also signalling hubs involved in a myriad of physiological functions. Although impairment of primary cilia and lipid rafts is associated with various diseases, the relationship between primary cilia and lipid rafts is poorly understood. Here, we review a newly discovered interaction between primary cilia and lipid raft dynamics that occurs during Akt signalling in adipogenesis. We also discuss the relationship between primary cilia and lipid raft-mediated Akt signalling in cancer biology. This review provides a novel perspective on primary cilia in the regulation of lipid raft dynamics.