ROS-induced cell cycle arrest as a mechanism of resistance in polyaneuploid cancer cells (PACCs). (October 2021)

• Record Type: Journal Article
• Authors: Kuczler, Morgan D.; Olseen, Athen M.; Pienta, Kenneth J.; Amend, Sarah R.
• Is Part Of: Progress in biophysics and molecular biology. Volume 165(2021)
• Page Start: 3
• Page End: 7
• Publication Date: 2021-10
• Subjects: Polyploid giant cancer cell (PGCC) -- Polyaneuploid cancer cell (PACC) -- Reactive oxygen species -- Cell cycle -- Therapy resistance; Biophysics -- Periodicals; Biochemistry -- Periodicals; Biophysics -- Periodicals; Molecular Biology -- Periodicals; Biophysique -- Périodiques; Biochimie -- Périodiques; 571.4
• DOI: 10.1016/j.pbiomolbio.2021.05.002
• Languages: English
• ISSNs: 0079-6107

Abstract

Abstract: Cancer is responsible for the deaths of millions of people worldwide each year. Once metastasized, the disease is incurable and shows resistance to all anti-cancer therapies. The already-elevated level of reactive oxygen species (ROS) in cancer cells is further increased by therapies. The oxidative stress activates the DNA damage response (DDR) and the stressed cancer cell moves towards cell cycle arrest. Once arrested, the majority of cancer cells will undergo programmed cell death in the form of apoptosis. If the cancer cell is able to exit the cell cycle prior to cell division and enter a protected G0 state, it is able to withstand and survive therapy as a polyaneuploid cancer cell (PACC) and eventually seed resistant tumor growth.