Serum trace elements levels and clinical outcomes among Iranian COVID-19 patients. (October 2021)

• Record Type: Journal Article
• Authors: Bagher Pour, Ozra; Yahyavi, Yahya; Karimi, Abbas; Khamaneh, Amir Mehdi; Milani, Mortaza; Khalili, Majid; Sharifi, Akbar
• Is Part Of: International journal of infectious diseases. Volume 111(2021)
• Page Start: 164
• Page End: 168
• Publication Date: 2021-10
• Subjects: COVID-19 -- Trace Elements -- Zinc -- Micronutrient -- Iran; Communicable diseases -- Periodicals; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; Electronic journals; 616.9
• DOI: 10.1016/j.ijid.2021.08.053
• Languages: English
• ISSNs: 1201-9712

Abstract

Highlights: 1 We studied Serum trace element levels that were not associated with disease severity 2 Zn serum levels were strongly associated with patient outcomes 3 Zn level can be considered a strong indicator for patients' outcomes Abstract: Objectives : The relationship between immunity and trace elements levels is well known. We aimed to estimate the association of serum trace elements with severity and outcomes in the Coronavirus Disease-2019 (COVID-19) patients. Methods: In this single-centered, prospective, observational study, we enrolled 114 patients admitted to severe intensive care units (ICUs) and corresponding 112 sex and aged-matched non-ICU ward patients. Demographic data, clinical characteristics, and outcomes were all collected. We analyzed serum levels of zinc (Zn), copper (Cu), selenium (Se), and manganese (Mn) in both severity groups. Results : The serum levels of Cu, Se, and Mn in both groups were within the normal range while Zn serum levels were lower than normal values. Based on these findings, Zn, Cu, Se, and Mn serum levels were not associated with disease severity ( P > 0.05), while we found Zn serum levels were strongly associated with patient outcomes ( P = 0.005). Our results indicated lower Mn serum levels were associated with age more than 55 years ( P = 0.006). Our results were not in favor of a causal relationship between serum trace elements levels and disease severity. Conclusion : We found Zn level to be a strong indicator for patients' outcomes that can be considered for monitoring patient prognosis. Nutritional measures or supplementation can help reduce poor outcomes caused by low Zn levels in Iranian COVID-19 patients.