The use of ANOVA-PCA and DD-SIMCA in the development of corn flour laboratory reference materials. (15th January 2022) - dos Santos, Liz O.
Highlights: The interlaboratory study to evaluate a candidate reference material was performed. The data was analyzed statistically applying the z-score robust technique. ANOVA-PCA was applied to evaluation of the data of stability. DD-SIMCA was applied for the first time to evaluation of the data of interlaboratory. The multivariate analysis can be applied in a alternative way to the recommended ISO. Abstract: The development of a collaborative study as a requirement for the preparation of a laboratory reference material candidate is reported in this paper. The evaluation was performed by 13 laboratories invited to quantify the calcium, potassium, magnesium, phosphorus, copper, iron, manganese and zinc; 8 of them presented results for all the analytes under investigation. The data were statistically analyzed by applying the z-score robust technique as recommended by ISO Guide 35. For the potassium element, laboratories 4 and 13 presented questionable results. Laboratory 5 proved to be unsatisfactory for calcium and zinc. ANOVA-PCA and DD-SIMCA were also applied to evaluate stability and interlaboratory studies results, respectively. It has been demonstrated that multivariate data analysis can be successfully applied as an alternative method to the recommendations made by ISO 13528 and ISO Guide 35 with defined confidence intervals.